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Thermosensitive hydrogel made of ferulic acid-gelatin and chitosan glycerophosphate
Author/Authors :
Cheng، نويسنده , , Yung-Hsin and Yang، نويسنده , , Shuhua and Liu، نويسنده , , Chia-Ching and Gefen، نويسنده , , Amit and Lin، نويسنده , , Feng-Huei، نويسنده ,
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روزنامه با شماره پیاپی سال 2013
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Abstract :
Reactive oxygen species-induced oxidative stress is involved in apoptosis of nucleus pulposus (NP) cells that can alter cellular phenotype and accelerate disc degeneration. Ferulic acid (FA) possesses an excellent antioxidant and anti-inflammatory properties. In the study, we developed the thermosensitive FA–gelatin/chitosan/glycerol phosphate (FA–G/C/GP) hydrogel which was applied as a sustained release system of FA to treat NP cells from the damage caused by oxidative stress. The gelation temperature of the FA–G/C/GP hydrogel was 32.17 °C. NP cells submitted to oxidative stress promoted by H2O2, and post-treated with FA–G/C/GP exhibited down-regulation of MMP-3 and up-regulation aggrecan and type II collagen in mRNA level. The sulfated-glycosaminoglycan production was increased and the apoptosis was inhibited in the post-treatment group. The results suggest that the thermosensitive FA–G/C/GP hydrogel can treat NP cells from the damage caused by oxidative stress and may apply in minimally invasive surgery for NP regeneration.
Keywords :
ferulic acid , Thermosensitive hydrogel , oxidative stress , Nucleus pulposus
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