Record number :
Title of article :
Size-controlled self-aggregated N-acyl chitosan nanoparticles as a vitamin C carrier
Author/Authors :
Cho، نويسنده , , Youngjin and Kim، نويسنده , , Jun Tae and Park، نويسنده , , Hyun Jin، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2012
Pages :
From page :
To page :
Abstract :
N-acyl chitosans with various acyl chain lengths were synthesized to improve their hydrophobicity and stability in delivery system. N-acyl chitosan nanoparticles were fabricated by self-aggregation method and vitamin C was loaded into the particles. Particle sizes were ranged from 444 nm to 487 nm with various acyl chain lengths reduced to particle size 216–288 nm with vitamin C loading. Vitamin C in the N-acyl chitosan nanoparticles may cross-link and pull the particle wall resulting in reducing the particle size. N-acyl chitosan nanoparticles were characterized using FTIR, zeta potential, size analyzer, scanning electron microscope. The loading efficiency of vitamin C on N-acyl chitosan nanoparticles ranged 55–67% and increased the loading efficiency of vitamin C too, with N-acyl chain length. Vitamin C in N-acyl chitosan nanoparticles showed the controlled release properties at pH 1.3 and pH 7.4. Release rate of vitamin C load is reduced with increasing the length of acyl side chain.
Keywords :
Nanoparticle , Vitamin C , Delivery system , Self-aggregation method , N-acyl chitosan
Journal title :
Journal title :
Serial Year :
Link To Document :