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Title of article :
Synthesis and characterization of N-succinyl-chitosan and its self-assembly of nanospheres
Author/Authors :
Aiping، نويسنده , , ZHU Qing-tian، نويسنده , , Chen and Lanhua، نويسنده , , Yuan and Hao، نويسنده , , WU SHI-PING، نويسنده , , Lu، نويسنده ,
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روزنامه با شماره پیاپی سال 2006
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Abstract :
A simple and novel method was developed to synthesize successfully the N-succinyl-chitosan (NSCS). The NSCS was characterized by FTIR, 1H NMR, element analysis and XRD. NSCS can be self-assembly of well-dispersed and stable nanospheres in distilled water. The morphology of the nanosphere was investigated by transmission electron microscope (TEM) and shows 50–100 nm in diameter. The steady-state fluorescence spectroscopy indicates that the hydrophobic domain has been formed within these NSCS nanospheres. The assembly mechanisms are believed to be the intermolecular H-bonding of NSCS and hydrophobic interaction among the hydrophobic moieties in NSCS macromolecules. The in vitro cell culture indicates that NSCS has non-toxicity and cell-compatibility. Our results demonstrate that NSCS has great potential in the drug controlled release delivery.
Keywords :
Chitosan , N-Succinyl-chitosan , Nanosphere , SELF-ASSEMBLY
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