Record number :
Title of article :
Fast and efficient microscale radiosynthesis of 3′-deoxy-3′-[18F]fluorothymidine
Author/Authors :
Koag، نويسنده , , Myong Chul and Kim، نويسنده , , Hee Kwon and Kim، نويسنده , , Andrew Sungjoon، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2014
Pages :
From page :
To page :
Abstract :
Microscale radiosynthesis on a miniaturized device has been reported as a promising tool for positron emission tomography. Here, we studied miscroscale-level radiosynthetic conditions by examining several microscale reactions that affect the radiochemical yield of 3′-deoxy-3′-[18F]fluorothymidine ([18F]FLT). [18F]FLT was prepared with 3-N-Boc-5′-O-dimethoxytrityl-3′-O-nosyl-thymidine using the cartridge purification method. [18F]FLT was prepared with a yield of 71%, and the productʹs purity was greater than 99%. Our results provide a new guideline for microscale [18F]FLT radiosynthesis.
Keywords :
Radiosynthesis , Fluorine-18 , Microscale reaction , Positron emission tomography
Journal title :
Journal of Fluorine Chemistry
Link To Document :