Record number :
Title of article :
Highly efficient Cu(I)-catalyzed trifluoromethylation of aryl(heteroaryl) enol acetates with CF3 radicals derived from CF3SO2Na and TBHP at room temperature
Author/Authors :
Lu، نويسنده , , Yang and Li، نويسنده , , Yaming and Zhang، نويسنده , , Zhuo-Rong and Jin، نويسنده , , Kun and Duan، نويسنده , , Chunying، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2014
Pages :
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Abstract :
An efficient method for the Cu(I)-catalyzed synthesis of α-trifluoromethyl ketones via the addition of CF3 to aryl(heteroaryl) enol acetates by using the readily available CF3SO2Na (Langlois reagent) has been developed. The reaction is experimentally simple and carried out at room temperature, providing good to excellent yields with wide functional group tolerance.
Keywords :
trifluoromethylation , Enol acetates , Synthetic methods , radical addition , ?-CF3 ketone
Journal title :
Journal of Fluorine Chemistry
Link To Document :