Record number :
1603691
Title of article :
The enzymatic resolution of an α-fluoroamide by an acylase
Author/Authors :
Banks، نويسنده , , John Colvin and David King ، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2000
Pages :
4
From page :
235
To page :
238
Abstract :
The acylase from Aspergillus melleus was able to hydrolyse the amide bond of (S)-phenylalanine-N-2-(R,S)-fluoropropionamide and discriminate the diastereoisomers such that the (S,S)-diastereoisomer was hydrolysed by an order of magnitude faster than the (S,R)-diasteroisomer. The origin of the kinetic discrimination is attributed to both binding and kinetic effects.
Keywords :
Enzyme resolution , 19F-NMR , Aspergillus melleus , Acylase , ?-fluoroamide
Journal title :
Journal of Fluorine Chemistry
Serial Year :
2000
Link To Document :
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