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Title of article :
Modelling the compartmentalization of splicing factors
Author/Authors :
Carrero، نويسنده , , G. and Hendzel، نويسنده , , M.J. and de Vries، نويسنده , , G.، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2006
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Abstract :
Splicing factor (SF) compartments, also known as speckles, are heterogeneously distributed compartments within the nucleus of eukaryotic cells that are enriched in pre-mRNA SFs. We derive a fourth-order aggregation–diffusion model that describes a possible mechanism underlying the organization of SFs into speckles. The model incorporates two hypotheses, namely (1) that self-organization of dephosphorylated SFs, modulated by a phosphorylation–dephosphorylation cycle, is responsible for the formation and disappearance of speckles, and (2) that an underlying nuclear structure plays a major role in the organization of SFs. A linear stability analysis about homogeneous steady-state solutions of the model reveals how the self-interaction among dephosphorylated SFs can result in the onset of spatial patterns. A detailed bifurcation analysis of the model describes how phosphorylation and dephosphorylation modulate the onset of the compartmentalization of SFs.
Keywords :
Splicing factors , Aggregation , pattern formation , Nuclear speckles
Journal title :
Journal of Theoretical Biology
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