Record number :
1522463
Title of article :
Liquid chromatographic resolution of secondary amino alcohols on a chiral stationary phase based on (+)-(18-crown-6)-2,3,11,12-tetracarboxylic acid: Dependence of temperature effect on analyte structure
Author/Authors :
Choi، نويسنده , , Hee Jung and Park، نويسنده , , Young Ju and Hyun، نويسنده , , Myung Ho، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2007
Pages :
5
From page :
235
To page :
239
Abstract :
Two types of secondary amino alcohols were successfully resolved on a liquid chromatographic chiral stationary phase based on (+)-(18-crown-6)-2,3,11,12-tetracarboxylic acid. The secondary amino alcohols containing a secondary amino group connected directly to the stereogenic center were resolved much better than those containing a hydroxyl group attached directly to the stereogenic center. In addition, the dependence of the separation factor (α) on column temperature was exactly opposite for the two different types of secondary amino alcohols. From the thermodynamic calculations based on Van’t Hoff plots, we conclude that the enantioselectivity for the resolution of the secondary amino alcohols containing a secondary amino group connected directly to the stereogenic center is enthalpically controlled while that for the resolution of the secondary amino alcohols containing a hydroxyl group attached directly to the stereogenic center is entropically controlled.
Keywords :
Enantiomer separation , Liquid chromatography , Chiral crown ether , Chiral Stationary Phase , Chiral secondary amino alcohols
Journal title :
Journal of Chromatography A
Journal title :
Journal of Chromatography A
Serial Year :
2007
Link To Document :
بازگشت