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Title of article :
Non-aqueous capillary electrophoretic separation of enantiomeric amines with (−)-2,3:4,6-di-O-isopropylidene-2-keto-l-gulonic acid as chiral counter ion
Author/Authors :
Carlsson، نويسنده , , Ylva and Hedeland، نويسنده , , Mikael and Bondesson، نويسنده , , Ulf and Pettersson، نويسنده , , Curt، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2001
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Abstract :
(−)-2,3:4,6-Di-O-isopropylidene-2-keto-l-gulonic acid [(−)-DIKGA] has been introduced as a chiral counter ion in non-aqueous capillary electrophoresis. High enantioresolutions (RS≥3) were obtained for amines, e.g., pronethalol, labetalol and bambuterol. Methanol containing NaOH and (−)-DIKGA was used as the background electrolyte. The counter ion concentration and the nature of the injection medium were found to affect the chiral separation. Covalent coating of the fused-silica capillary reduced the electro-osmotic flow resulting in improved enantioresolutions.
Keywords :
Amines , Labetalol , Diisopropylideneketogulonic acid
Journal title :
Journal of Chromatography A
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Link To Document :