Record number :
1466455
Title of article :
Liquid chromatographic direct resolution of aryl α-amino ketones on a residual silanol group-protecting chiral stationary phase based on optically active (3,3′-diphenyl-1,1′-binaphthyl)-20-crown-6
Author/Authors :
Choi، نويسنده , , Hee Jung and Jin، نويسنده , , Jong Sung and Hyun، نويسنده , , Myung Ho، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2008
Pages :
6
From page :
102
To page :
107
Abstract :
A residual silanol group-protecting chiral stationary phase (CSP) based on optically active (3,3′-diphenyl-1,1′-binaphthyl)-20-crown-6 was successfully applied to the resolution of racemic cathinone and it analogue aryl α-amino ketones. The separation factors (α) and the resolutions (RS) for 12 analytes were in the ranges of 2.85–16.12 and 6.49–19.64, respectively. The chromatographic resolution behaviors were investigated as a function of the content and type of organic and acidic modifiers and the ammonium acetate concentration in aqueous mobile phase. The practical usefulness of the CSP in the determination of the enantiomeric purity of optically active cathinone and in the preparative resolution of racemic cathinone was demonstrated.
Keywords :
Cathinone , Aryl ?-amino ketone , Chiral Stationary Phase , 3?-Diphenyl-1 , 1?-binaphthyl)-20-crown-6 , Liquid chromatography , Enantiomer separation , (3
Journal title :
Journal of Chromatography B
Journal title :
Journal of Chromatography B
Serial Year :
2008
Link To Document :
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