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Title of article :
Changes of the cortex proteome and Apolipoprotein E in transgenic mouse models of Alzheimerʹs Disease
Author/Authors :
Carrette، نويسنده , , O. and Burgess، نويسنده , , J.A. and Burkhard، نويسنده , , P.R. and Lang، نويسنده , , C. M. Cote، نويسنده , , M. and Rodrigo، نويسنده , , N. and Hochstrasser، نويسنده , , D.F. and Sanchez، نويسنده , , J.-C.، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2006
Pages :
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Abstract :
Transgenic mice carrying human Amyloid Precursor Protein mutations present amyloid plaque deposition in the brain upon aging. In this study, we characterized the changes of cortex proteome and endogenous Apolipoprotein E in these mice. Differential analysis of two-dimensional electrophoresis images revealed spots altered upon aging, transgene addition and plaque deposition. Alpha-synuclein and cytochrome oxidase polypeptide Va were up-regulated in transgenic mice. Upon aging, expression of ATP synthase α, α enolase, UMP-CMP kinase, and dihydropyrimidinase like-2 protein was modified. These proteins and their modification probably play a role in the amyloid aggregate formation in these mice.
Keywords :
Alzheimerיs disease , Transgenic mice , Two-dimensional electrophoresis , Cortex
Journal title :
Journal of Chromatography B
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Link To Document :