Title of article :
Determination of mirtazapine in human plasma by liquid chromatography
Pt??ek، نويسنده , , P and Kl??ma، نويسنده , , J and Macek، نويسنده , , J، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2003
A rapid high-performance liquid chromatographic method for the quantitation of mirtazapine in human plasma is presented. The method is based on a liquid–liquid extraction and reversed-phase chromatography with fluorimetric detection. The separation was performed on a Luna 3-μm C18(2) 50×4.6 mm I.D. column using an isocratic elution. Zolpidem hemitartrate was used as the internal standard. The between-day precision expressed by relative standard deviation was less than 5% and inaccuracy does not exceed 6%. A low limit of quantitation (1.5 ng/ml) and a short time of analysis (4 min) makes this assay suitable for pharmacokinetic studies.
Journal title :
Journal of Chromatography B