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Title of article :
An imprinted fluorescent chemosensor prepared using dansyl-modified β-cyclodextrin as the functional monomer for sensing of cholesterol with tailor-made selectivity
Author/Authors :
Cheng، نويسنده , , Yang and Jiang، نويسنده , , Ping and Lin، نويسنده , , Shen and Li، نويسنده , , Yongna and Dong، نويسنده , , Xiangchao، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2014
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Abstract :
A novel cholesterol-imprinted fluorescent chemosensor was synthesized by molecular imprinting technique. In the molecular imprinting, dansyl-modified β-cyclodextrin (β-CD-en-DNS) was used as the functional monomer that formed a complex with cholesterol by inclusion interactions. The membrane chemosensor responded to the addition of cholesterol via a “turn off” mode. The chemosensor has selectivity for cholesterol, which differs from that of the monomer β-CD-en-DNS. This tailor-made response of the chemosensor demonstrated that imprinted binding sites were formed. The 2D 1H NMR experiment indicated that one cholesterol molecule interacted with two β-CDs to form binding receptors for the analyte. In the present study, the fluorescence change of dansyl groups with the variation of the environment due to the in-out of the CD cavity was utilized to signal the binding of the analytes. This sensing mechanism can be utilized by the compounds which have inclusion interaction with β-CD. It provided more applications in the fabrication of imprinted fluorescent chemosensors by molecular imprinting technique. Meanwhile, because β-CD is water soluble and can include neutral compounds, this imprinted chemosensor has advantage in the recognition of organic analytes in the aqueous solution.
Keywords :
Molecular imprinted membrane , Cholesterol , Dansyl-modified cyclodextrin , Fluorescent chemosensor
Journal title :
Sensors and Actuators B: Chemical
Journal title :
Sensors and Actuators B: Chemical
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