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Title of article :
Is successful electroconvulsive therapy related to stimulation of the vagal system?
Author/Authors :
Bنr، نويسنده , , Karl-Jürgen and Ebert، نويسنده , , Andreas and Boettger، نويسنده , , Michael Karl and Merz، نويسنده , , Sebastian and Kiehntopf، نويسنده , , Michael and Jochum، نويسنده , , Thomas and Juckel، نويسنده , , Georg and Agelink، نويسنده , , Marcus Willi، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2010
Pages :
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Abstract :
Background oconvulsive therapy (ECT) has been shown to exhibit strong beneficial effects in the treatment of major depressive disorder (MDD). While the exact underlying mechanisms are under debate, a role for the sympathetic response upon ECT has been suggested. When assessing patients with MDD for autonomic function, however, a loss of vagal function is prominent. ive we aimed to assess the immediate effects of ECT on vagal activity and to test the hypothesis that surrogates of the latter correlate with therapeutic outcome. s patients with MDD who underwent ECT treatment were assessed regarding their vagal function using electrophysiological measures and determination of pancreatic polypeptide (PP), which is known to be released upon vagal stimulation. Parameters were correlated to the improvement of disease severity upon ECT treatment. s ts showed a significant increase of PP shortly after ECT which correlated with clinical improvement. Furthermore, the described association with the sympathetic phase after ECT could be verified. sion creases vagal activity which might be associated with the beneficial effect seen following this treatment. PP elevation after administration of ECT might be a useful parameter to estimate the degree of such vagal stimulation after treatment.
Keywords :
Therapeutic effect , Parasympathetic Nervous System , pancreatic polypeptide , electroconvulsive therapy , Sympathetic Nervous System , Major depressive disorder
Journal title :
Journal of Affective Disorders
Journal title :
Journal of Affective Disorders
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