Record number :
1431769
Title of article :
Regional homogeneity in depression and its relationship with separate depressive symptom clusters: A resting-state fMRI study
Author/Authors :
Yao، نويسنده , , Zhijian and Wang، نويسنده , , Li and Lu، نويسنده , , Qing and Liu، نويسنده , , Haiyan and Teng، نويسنده , , Gaojun Wen، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2009
Pages :
9
From page :
430
To page :
438
Abstract :
Background a newly reported regional homogeneity (ReHo) approach, we were to explore the features of brain activity of patients with major depressive disorder (MDD) in resting state, and further to examine the relationship between abnormal brain activity of depressed patients and specific symptom clusters derived from ratings on the Hamilton Rating Scale for Depression (HRSD). s ients with MDD and 22 gender-, age-, and education-matched healthy subjects participated in the fMRI scans. s ed with healthy controls, decreased ReHo were found in depressed patients in the right orbitofrontal cortex, the right fusiform gyrus, the right ventral anterior cingulate gyrus, the left dorsal anterior cingulate gyrus, the right posterior cingulate gyrus, the left lentiform nucleus and the right insula (p < 0.005, uncorrected). y severity was positively correlated with the ReHo in the right insula; Cognitive disturbance severity was positively correlated with the ReHo in the right orbitofrontal cortex and the left dorsal anterior cingulate gyrus; Retardation severity was positively correlated with the ReHo in the right posterior cingulate gyrus and the right insula; Sleep disturbance severity was positively correlated with the ReHo in the left dorsal anterior cingulate gyrus; Hopelessness severity was positively correlated with the ReHo in the right ventral anterior cingulate gyrus and the right insula (p < 0.05). tion fluence of antidepressant medication to the brain activity of depressed patients was not fully excluded. sions ndings indicated abnormal brain activity was distributed extensively in depressed patients during resting state, and some symptom domains of depression are separately related to specific abnormal patterns of brain activity.
Keywords :
Depressive disorders , FMRI , Regional homogeneity , Hamilton Rating Scale for Depression , Resting state
Journal title :
Journal of Affective Disorders
Link To Document :