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Title of article :
Porous wollastonite–hydroxyapatite bioceramics from a preceramic polymer and micro- or nano-sized fillers
Author/Authors :
Bernardo، نويسنده , , Enrico and Colombo، نويسنده , , Paolo and Cacciotti، نويسنده , , Ilaria and Bianco، نويسنده , , Alessandra and Bedini، نويسنده , , Rossella and Pecci، نويسنده , , Raffaella and Pardun، نويسنده , , Karoline and Treccani، نويسنده , , Laura and Rezwan، نويسنده , , Kurosch Rezwan، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2012
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Abstract :
Wollastonite–hydroxyapatite ceramics have been successfully prepared by a novel method, corresponding to the thermal treatment in air of a silicone embedding micro- and nano-sized fillers. CaCO3 nano-sized particles, providing CaO upon decomposition, acted as “active” filler, whereas different commercially available or synthesised hydroxyapatite particles were used as “passive” filler. The homogeneous distribution of CaO, at a quasi-molecular level, favoured the reaction with silica derived from the polymer, at only 900 °C, preventing extensive decomposition of hydroxyapatite. Open-celled porous ceramics suitable for scaffolds for bone–tissue engineering applications were easily prepared from filler-containing silicone resin mixed with sacrificial PMMA microbeads as templates. The pore size (in the range of 80–400 μm) and the open porosity percentage (40–50%) were evaluated by means of micro-computerized tomographic analysis. A preliminary assessment of the biocompatibility and cell activity of the produced ceramics was performed successfully by in vitro tests using human osteoblast cells.
Keywords :
D. Silicate , A. Precursors , B. Nanocomposites , E. Biomedical applications , D. Apatite
Journal title :
Journal of the European Ceramic Society
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