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Title of article :
A new magnetic bead-based, filterless bio-separator with planar electromagnet surfaces for integrated bio-detection systems
Author/Authors :
Choi، نويسنده , , Jin-Woo and Ahn، نويسنده , , Chong H and Bhansali، نويسنده , , Shekhar and Henderson، نويسنده , , H.Thurman، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2000
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Abstract :
A new filterless bio-separator separating magnetic microbeads from a carrier fluid has been designed, fabricated, and characterized as a core component of biological cell sampling and detecting systems. To maximize the sampling capability, a planar electromagnet surface with a serpentine coil and semi-encapsulated permalloy has been realized. Using this bio-separator, antibody-coated magnetic beads have been successfully separated from the bio-buffer suspension solution and characterized in dynamic fluid flow. The magnetic characteristics of the bio-separator have been simulated and experimentally studied to establish and validate the design rules for fabrication. The realized filterless bio-separator has a high potential in biomedical and biological detection systems. It is especially useful in selective sampling and separation of small amounts of bio-molecules (e.g., antigen) for on-chip micro total analysis systems (μ-TAS) or remote detection systems.
Keywords :
Magnetic beads , sampling , detection , Bio-separator
Journal title :
Sensors and Actuators B: Chemical
Journal title :
Sensors and Actuators B: Chemical
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Link To Document :