Record number :
Title of article :
Palladium-catalyzed direct 5-arylation of formyl- or acetyl-halothiophene derivatives
Author/Authors :
Kassem Beydoun، نويسنده , , Henri Doucet، نويسنده ,
Issue Information :
دوفصلنامه با شماره پیاپی سال 2011
Pages :
From page :
To page :
Abstract :
Pd(OAc)2 was found to catalyze the direct arylation of some functionalized halothiophene derivatives allowing the synthesis in only one step of polyfunctionalized arylated thiophenes. In the presence of 2-acetyl-3-chlorothiophene, 2-acetyl-4-chlorothiophene, 2-acetyl-3-bromothiophene diethylacetal or 2-(4-bromothiophen-2-yl)-[1,3]dioxolane, and a variety of aryl bromides, the 5-arylation products were obtained in moderate to high yields employing only 0.5 mol% catalyst. On the other hand, the use of 2-formyl-3-chlorothiophene, 2-acetyl-3-bromothiophene or 2-formyl-3-bromothiophene gave disappointing results.
Keywords :
aryl halides , Catalysis , C–H activation , Thiophenes , Palladium
Journal title :
Journal of Organometallic Chemistry
Link To Document :