Title of article :
Co-opted integrin signaling in ErbB2-induced mammary tumor progression
Carraway III، نويسنده , , Kermit L. and Sweeney، نويسنده , , Colleen، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2006
Although almost two decades of study point to a central role for aberrant ErbB2 activation in breast cancer, many cellular and biochemical mechanisms underlying ErbB2-induced tumor initiation and progression remain to be resolved. A study by Guo et al. published recently in Cell indicates that the signaling function of β4 integrin actively contributes to the initiation, growth, and invasion of ErbB2-induced mammary tumors in transgenic mice by promoting the activation of c-Jun and STAT3. These observations offer novel mechanistic insight into ErbB2 action and highlight the notion that ErbB2 co-opts the functions of other signaling proteins to elicit tumor progression.
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