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Title of article :
Protein farnesyltransferase in embryogenesis, adult homeostasis, and tumor development
Author/Authors :
Carmen and Mijimolle، نويسنده , , Nieves and Velasco، نويسنده , , Juan and Dubus، نويسنده , , Pierre and Guerra، نويسنده , , Carmen and Weinbaum، نويسنده , , Carolyn A. and Casey، نويسنده , , Patrick J. and Campuzano، نويسنده , , Victoria and Barbacid، نويسنده , , Mariano، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2005
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Abstract :
Summary n farnesyltransferase (FTase) is an enzyme responsible for posttranslational modification of proteins carrying a carboxy-terminal CaaX motif. Farnesylation allows substrates to interact with membranes and protein targets. Using gene-targeted mice, we report that FTase is essential for embryonic development, but dispensable for adult homeostasis. Six-month-old FTase-deficient mice display delayed wound healing and maturation defects in erythroid cells. Embryonic fibroblasts lacking FTase have a flat morphology and reduced motility and proliferation rates. Ablation of FTase in two ras oncogene-dependent tumor models has no significant consequences for tumor initiation. However, elimination of FTase during tumor progression had a limited but significant inhibitory effect. These results should help to better understand the role of protein farnesylation in normal tissues and in tumor development.
Journal title :
Cancer Cell
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