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Title of article :
A hydrophilic chiral diamine from d-glucose in the Rh(I) catalysed asymmetric hydrogenation of acetophenone
Author/Authors :
Carmela Borriello، نويسنده , , Maria Elena Cucciolito، نويسنده , , Achille Panunzi، نويسنده , , Francesco Ruffo، نويسنده , , Angela Saporito، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2003
Pages :
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Abstract :
A strategy for the synthesis of a new hydrophilic chiral diamine derived from α-d-glucose is described. The compound is obtained by introducing proper nitrogen functions at C2 and C3 positions of the sugar ring, and by deprotecting positions 4 and 6. The efficiency of the ligand in the Rh(I)-catalysed hydrogenation of acetophenone has been examined by using isopropanol and ethanol as hydrogen sources. The secondary alcohol has been obtained in ees up to 50%.
Keywords :
Carbohydrates , Rhodium , asymmetric hydrogenation , Nitrogen ligands
Journal title :
Inorganic Chemistry Communications
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Link To Document :