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Title of article :
New fluorinated derivatives as esterase inhibitors. Synthesis, hydration and crossed specificity studies Original Research Article
Author/Authors :
Carmen Quero، نويسنده , , Gloria Rosell، نويسنده , , Oscar Jiménez، نويسنده , , Sergio Rodriguez، نويسنده , , M.Pilar Bosch، نويسنده , , Angel Guerrero، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2003
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Abstract :
A variety of new fluorinated chemicals have been prepared for the first time and tested as inhibitors of esterases, one of the main enzymes involved in pheromone catabolism, in two economically important pests, the Egyptian armyworm Spodoptera littoralis (SL) and the Mediterranean corn borer Sesamia nonagrioides (SN). Using the respective major component of the pheromone as substrate, the Km and Vmax of the antennal esterase of both insects resulted to be 5.66×10−4 M and 8.47×10−6 Mmin−1 for SL and 1.61×10−7 M and 1.25×10−7 Mmin−1 for SN, pointing out that SN esterase has a higher affinity for its corresponding substrate than SL. In general, the trifluoromethyl ketones (TFMKs) exhibited higher inhibitory potency than the corresponding difluoromethyl ketones (DFMKs) or difluoroaldehydes (DFAs). The compounds appeared to hydrate differently in aqueous solution, the extent of hydration following the order: α,α-DFMKs<α,α-difluoro-β-thioalkylmethyl ketones
Journal title :
Bioorganic and Medicinal Chemistry
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