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Title of article :
Structure–activity relationships in a series of 8-substituted xanthines as A1-adenosine receptor antagonists Original Research Article
Author/Authors :
Giovannella Strappaghetti، نويسنده , , Stefano Corsano، نويسنده , , Roberta Barbaro، نويسنده , , Gino Giannaccini، نويسنده , , Laura Betti، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2001
Pages :
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Abstract :
A series of 8-substituted xanthines were synthesized and their affinity in vitro towards A1, A2A-adenosine receptors was evaluated by radioligand receptor binding assays. All compounds showed a greater affinity and selectivity towards the A1-adenosine receptor than theophylline. The compounds in which the n-proyl group is in 1-position of the xanthine nucleus and the pyridazinone system in 8-position is linked through a chain of two or four carbon atoms, showed the highest affinity and selectivity.
Journal title :
Bioorganic and Medicinal Chemistry
Link To Document :