Record number :
1301144
Title of article :
Studies on duocarmycin SA and its derivatives Original Research Article
Author/Authors :
Satoru Nagamura، نويسنده , , Akira Asai، نويسنده , , Eiji Kobayashi، نويسنده , , Katsushige Gomi، نويسنده , , Hiromitsu Saito، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 1997
Pages :
8
From page :
623
To page :
630
Abstract :
New duocarmycin SA derivatives have been synthesized and evaluated for in vitro anticellular activity against HeLa S3 cells, and in vivo antitumor activity against murine sarcoma 180 in mice. The results suggested that the N,N-dialkylcarbamoyl derivatives bearing the p-methoxy cinnamoyl group, which was prepared from duocarmycin SA, showed good in vivo antitumor activities superior to native duocarmycin SA. We described the synthesis and antitumor activity of a new type of duocarmycin SA.
Journal title :
Bioorganic and Medicinal Chemistry
Link To Document :