Record number :
Title of article :
Synthesis and antitumor activity of some indeno[1,2-b]quinoline-based bis carboxamides Original Research Article
Author/Authors :
Leslie W. Deady، نويسنده , , José Desneves، نويسنده , , Anthony J. Kaye، نويسنده , , Graeme J. Finlay، نويسنده , , Bruce C. Baguley، نويسنده , , William A. Denny، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2000
Pages :
From page :
To page :
Abstract :
A series of bis(11-oxo-11H-indeno[1,2-b]quinoline-6-carboxamides) linked through the 6-carboxamides were prepared by coupling the requisite acid imidazolides with various diamines. Compounds with mono-cationic linker chains were more potent cytotoxins than the corresponding monomer in a panel of rodent and human cell lines, while those with the dicationic linker chains (CH2)2NR(CH2)2NR(CH2)2 and (CH2)2NR(CH2)3NR(CH2)2 showed extraordinarily high potencies (for example, IC50s of 0.18–1.4 nM against human Jurkat leukemia; up to 1000-fold more potent than the parent monomer). As seen previously in the monomeric series, small, lipophilic 4-substituents significantly increased potency in cell culture. The dimeric compounds were all slightly to significantly more potent in the mutant JLA and JLD cell lines that under-express topo II, suggesting that this enzyme is not their primary target. An 11-imino-linked dimer was much less active, and an asymmetric indeno[1,2-b]quinoline-6-carboxamide/naphthalimide dimer was less active than the comparable symmetric bis(indeno[1,2-b]quinoline-6-carboxamide). Selected analogues were active against sub-cutaneously implanted colon 38 tumors in mice, giving growth delays comparable to that of the clinical topo I inhibitor irinotecan at up to 10-fold lower doses. These compounds form an interesting new class of putative topo I inhibitors.
Journal title :
Bioorganic and Medicinal Chemistry
Link To Document :