Record number :
1300851
Title of article :
Novel potassium channel openers. Part 4: transformation of the 1,4-benzoxazine skeleton into 1,4-benzothiazine, 1,2,3,4-tetrahydroquinoline, 1,2,3,4-tetrahydroquinoxaline, indoline, and 1,5-benzoxazepine Original Research Article
Author/Authors :
Yuzo Matsumoto، نويسنده , , Ryuji Tsuzuki، نويسنده , , Akira Matsuhisa، نويسنده , , Toru Yoden، نويسنده , , Yoko Yamagiwa، نويسنده , , Isao Yanagisawa، نويسنده , , Tadao Shibanuma، نويسنده , , Hiroyuki Nohira، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2000
Pages :
12
From page :
393
To page :
404
Abstract :
As part of a search for a new potassium channel opener, the 1,4-benzoxazine skeleton derived from the benzopyran skeleton of cromakalim, was transformed into other fused rings such as 1,4-benzothiazine, 1,2,3,4-tetrahydroquinoline, 1,2,3,4-tetrahydroquinoxaline, indoline, and 1,5-benzoxazepine. The 1,4-benzothiazine derivative displayed approximately 20 times more potent vasorelaxant activity than cromakalim.
Keywords :
potassium channel openers , vasodilators , Antihypertension , cardiovascular activity
Journal title :
Bioorganic and Medicinal Chemistry
Journal title :
Bioorganic and Medicinal Chemistry
Serial Year :
2000
Link To Document :
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