Record number :
1300747
Title of article :
Studies on the synthesis and biological activities of 4′-(R)-hydroxy-5′-(S)-hydroxymethyl-tetrahydrofuranyl purines and pyrimidines Original Research Article
Author/Authors :
Hongwu Yu، نويسنده , , Liangren Zhang، نويسنده , , Ji-Chang Zhou، نويسنده , , Lingtai Ma، نويسنده , , Li-He Zhang، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 1996
Pages :
6
From page :
609
To page :
614
Abstract :
A series of 4′-(R)-hydroxy-5′-(S)-hydroxymethyl-tetrahydrofuranyl purines and pyrimidines were synthesized by the reaction of 3,4-epoxy-5-(S,trans)-dimethoxymethyl-tetrahydrofuran and nucleobases under the catalysis of potassium tert-butoxide and 18-crown-6. Compounds 6a, 6c and 7b have shown significant inhibition on the growth of HL-60 cells. The phosphotriester and phosphodiester of isonucleoside 8a-d were synthesized and cytotoxic activities were reported. The conformation of isonucleosides in solution was studied by 1H NMR.
Keywords :
Cytotoxicity , HSV type II , anti-HSV type I , conformation , Stereochemistry , Isonucleoside
Journal title :
Bioorganic and Medicinal Chemistry
Link To Document :