Record number :
1300603
Title of article :
The absolute configuration of adjacent bis-THF acetogenins and asiminocin, a novel highly potent asimicin isomer from Asimina triloba Original Research Article
Author/Authors :
Geng-Xian Zhao، نويسنده , , Jin-Feng Chao، نويسنده , , Lu Zeng، نويسنده , , Matthew J. Rieser، نويسنده , , Jerry L. McLaughlin، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 1996
Pages :
8
From page :
25
To page :
32
Abstract :
A novel acetogenin, asiminocin (1), was isolated by activity-directed fractionation from the stem bark of the paw paw tree, Asimina triloba. By spectral and chemical methods, 1 was identified as (30S)-hydroxy-4-deoxyasimicin. The absolute configuration of 1, along with those of previously reported acetogenins asimin, asiminacin, bullatin, (30S)-bullanin, and (30R) bullanin, was determined by Mosher ester methodology. Compound 1 was highly inhibitory to three human solid tumor cell lines with over a billion times the potency of adriamycin.
Journal title :
Bioorganic and Medicinal Chemistry
Link To Document :