Record number :
Title of article :
Synthesis and antiviral effects of 2-heteroaryl substituted adenosine and 8-heteroaryl substituted guanosine derivatives Original Research Article
Author/Authors :
Tina Persson، نويسنده , , Salo Gronowitz، نويسنده , , Anna-Britta H?rnfeldt، نويسنده , , Nils Gunnar Johansson، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 1995
Pages :
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Abstract :
2-(2″- and 3″-Thienyl)adenosine and the corresponding furyl derivatives were prepared through Pd(0)-catalyzed coupling of 2′,3′,5′-tri-O-(t-butyldimethylsilyl)-2-iodoadenosine with the appropriate tributyltin derivatives followed by deprotection. Preparation of the 8-(2″- and 3″-thienyl)guanosines and 8-(2″- and 3″-furyl)guanosines followed a similar route. Antiviral properties of these compounds and the related 2,6-diaminopurine ribofuranosides were of no pharmacological interest.
Journal title :
Bioorganic and Medicinal Chemistry
Link To Document :