Record number :
1300422
Title of article :
Nucleosides and nucleotides—CXXXVII. Antitumor phospholipids with 5-fluorouridine as a cytotoxic polar-head: Synthesis of 5′-phosphatidyl-5-fluorouridines by phospholipase d-catalyzed transphosphatidylation Original Research Article
Author/Authors :
Satoshi Shuto، نويسنده , , Hiromichi Itoh، نويسنده , , Atsushi Sakai، نويسنده , , Keishi Nakagami، نويسنده , , Shigeyuki Imamura، نويسنده , , Akira Matsuda and Fuyuhiko Inagaki، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 1995
Pages :
9
From page :
235
To page :
243
Abstract :
5′-Phosphatidyl-5-fluorouridines, with the same backbone structure as that of natural phospholipids, in which a polar-head group of usual phospholipids is replaced by 5-fluorouridine, were designed to be potent antitumor agents. 5′-Phosphatidyl-5-fluorouridines with a variety of diacyl or dialkyl residues in the glycerol moiety, were synthesized by phospholipase D-catalyzed transphosphatidylation from the corresponding phosphatidylcholine and 5-fluorouridine. These new compounds were evaluated in mice with experimental tumors by ip and po administration. Dipalmitoyl and distearoyl derivatives 1b and 1c had the greatest antitumor activity against both P388 leukemia and Meth A fibrosarcoma in mice.
Journal title :
Bioorganic and Medicinal Chemistry
Link To Document :