Record number :
1300277
Title of article :
Polychlorinated biphenyl 153 is a diet-dependent obesogen that worsens nonalcoholic fatty liver disease in male C57BL6/J mice
Author/Authors :
Banrida Wahlang، نويسنده , , K. Cameron Falkner، نويسنده , , Bonnie Gregory، نويسنده , , Douglas Ansert، نويسنده , , David Young، نويسنده , , Daniel J. Conklin، نويسنده , , Aruni Bhatnagar، نويسنده , , Craig J. McClain، نويسنده , , Matt Cave، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2013
Pages :
9
From page :
1587
To page :
1595
Abstract :
In control diet-fed mice, addition of PCB 153 had minimal effects on any of the measured parameters. However, PCB 153 treatment in high-fat-fed mice was associated with increased visceral adiposity, hepatic steatosis and plasma adipokines including adiponectin, leptin, resistin and plasminogen activator inhibitor-1 levels. Likewise, coexposure reduced expression of hepatic genes implicated in β-oxidation while increasing the expression of genes associated with lipid biosynthesis. Regardless of diet, PCB 153 had no effect on insulin resistance or tumor necrosis factor alpha levels.
Keywords :
NAFLD , PCB , PCBS , TASH , POPs
Journal title :
The Journal of Nutritional Biochemistry
Link To Document :