Banihashem ، A نويسنده Associated Professor of Pediatric Hematology & Oncology, faculty of medicine, Mashhad University of Medical Sciences, Mashhad, Iran. , , Ghasemi ، A نويسنده Assistant Professor of Pediatric Hematology & Onc1 Associated Professor of Pediatric Hematology & Oncology, faculty of medicine, Mashhad University of , , Ghaemi ، N نويسنده Associate Professor of Pediatric Endocrinology, Mashhad University of Medical Sciences, Ghaem Hospital, Mashhad, Iran. , , Moazzen ، N نويسنده Pediatrician, Mashhad University of Medical Sciences, Mashhad, Iran. , , Amirabadi ، A نويسنده Radiation oncologist, cancer research center, Mashhad University of medical sciences, Mashhad, Iran. ,
The most common malignancy of children is Leukemia, accounting approximately one third of cancer diagnosis. Available data demonstrate improvement in survival of pediatric leukemia, so evaluation of side effects of treatment is very important. This study investigates hyperglycemia and diabetes mellitus prevalence in pediatric patients with acute leukemia.
Materials and Methods
This study was performed in children with acute leukemia. At the first admission, demographic data was collected and blood glucose and HbA1c levels were obtained. These tests examined at least two times during six months of follow up. Growth parameters and blood samples were obtained too.
Twenty nine patients were examined; three of them (10.3%) had diabetes mellitus and 5patients (17.2%) had transient hyperglycemia.Mean age of the patients was 6.26 years and nineteen Children (63%) were in preschool age. In preschool age children, incidence of hyperglycemia was meaningfully higher than school age children (p= 0.02).
24 of 29 patients (82.7%) were known case of acute lymphoblastic leukemia (ALL) and 5 patients (17.3%) were known case of acute myeloblastic leukemia (AML). No significant difference was found between sex groups. Also underweight was significant risk factor for hyperglycemia.
The prevalence of hyperglycemia was in the range of other similar studies in different parts of the world. Underweight and preschool ages were significant predictors of hyperglycemia.