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Title of article :
New antimalarial polyketide endoperoxides from the marine sponge Plakinastrella mamillaris collected at Fiji Islands
Author/Authors :
Carmen Festa، نويسنده , , Simona De Marino، نويسنده , , Maria Valeria D’Auria، نويسنده , , Orazio Taglialatela-Scafati، نويسنده , , Eric Deharo، نويسنده , , Sylvain Petek، نويسنده , , Angela Zampella، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2013
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Abstract :
Plakortides R–U, four new polyketide endoperoxides, have been isolated from the marine sponge Plakinastrella mamillaris. Their structures were elucidated on the basis of extensive NMR spectroscopic (1H and 13C, COSY, HSQC, HMBC, and ROESY) and MS analyses and by chemical methods. In addition, a new method for the unambiguous stereochemical elucidation of 3,6-disubstituted 1,2-dioxines, frequently isolated from Plakinidae sponges, is reported. Pharmacological analysis demonstrated that plakortide U is endowed with in vitro antiplasmodial activity against a chloroquine-resistant strain.
Keywords :
Plakinastrella mamillaris , Polyketide endoperoxides , Marine compounds , antiplasmodial activity
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