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Title of article :
Asymmetric total synthesis of 5′-epi-cochliomycin C
Author/Authors :
Nandan Jana، نويسنده , , Debabrata Das، نويسنده , , Samik Nanda، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2013
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Abstract :
Asymmetric total synthesis of one of the stereoisomers of naturally occurring chlorine containing 14-membered ring macrolide cochliomycin-F (5′-epi) has been described in this article. The main highlight of the presented synthetic strategy involves a highly regioselective chlorination and Julia–Kocienski olefination with a highly substituted aromatic chloro-aldehyde to create the required E-olefinic unsaturation in the target molecule. Mitsunobu macrolactonization reaction at the late stage enables us to synthesize the target molecule.
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