Record number :
1105529
Title of article :
A new and efficient synthesis of 1,3,4-oxadiazole derivatives using TBTU
Author/Authors :
Shokoofeh Maghari، نويسنده , , Sorour Ramezanpour، نويسنده , , Fatemeh Darvish، نويسنده , , Saeed Balalaie، نويسنده , , Frank Rominger، نويسنده , , Hamid Reza Bijanzadeh، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2013
Pages :
6
From page :
2075
To page :
2080
Abstract :
An efficient method for the synthesis of 2,5-disubstituted 1,3,4-oxadiazoles from isothiocyanates and hydrazides through cyclodesulfurization in the presence of (O-(benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium tetrafluoroborate) TBTU as an uronium coupling reagent has been developed. The present methodology offers several advantages, such as simple and easy work-up procedures, mild reaction conditions and it is environmentally benign.
Keywords :
1 , 3 , 4-oxadiazole , TBTU , Isothiocyanate , Hydrazides , coupling reagent
Journal title :
Tetrahedron
Link To Document :