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Title of article :
Anti-inflammatory cyclopeptides from the marine sponge Theonella swinhoei
Author/Authors :
Carmen Festa، نويسنده , , Simona De Marino، نويسنده , , Maria Valeria D’Auria، نويسنده , , Maria Chiara Monti، نويسنده , , Mariarosaria Bucci، نويسنده , , Valentina Vellecco، نويسنده , , Cécile Debitus، نويسنده , , Angela Zampella، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2012
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Abstract :
DCCC chromatography followed by HPLC purification on the polar extract of marine sponge Theonella swinhoei resulted in the isolation of five new cyclopeptides, perthamides G–K. The new structures, featuring unprecedented amino acid units, were determined by interpretation of extensive spectroscopic and spectrometric data (MS, 1H and 13C NMR, COSY, HSQC, HMBC, and ROESY). Pharmacological analysis demonstrated that these natural cyclopeptides are endowed with anti-inflammatory potential as assessed by their ability to reduce carrageenan-induced mouse paw oedema.
Keywords :
Marine compounds , cyclopeptides , Theonella swinhoei , Anti-inflammatory activity
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