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Title of article :
Perthamides C–F, potent human antipsoriatic cyclopeptides
Author/Authors :
Carmen Festa، نويسنده , , Simona De Marino، نويسنده , , Valentina Sepe، نويسنده , , Maria Valeria D’Auria، نويسنده , , Giuseppe Bifulco، نويسنده , , Rosa Andrés، نويسنده , , Maria Carmen Terencio، نويسنده , , Miguel Payà Peris، نويسنده , , Cécile Debitus، نويسنده , , Angela Zampella، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2011
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Abstract :
Two new cyclopeptides, perthamides E and F were isolated from the polar extracts of the sponge Theonella swinhoei. The new structures, featuring an unprecedented β-amino acid unit (AHMOA), were determined by interpretation of NMR and MS data. The absolute configuration of the AHMOA residue was proposed on the basis of quantum chemical calculation of NMR chemical shifts. Perthamides were proved to inhibit TNF-α and IL-8 release in primary human keratinocytes cells and therefore could represent potentially leads for the treatment of psoriasis.
Keywords :
Marine compounds , Anti-inflammatory activity , Cyclic peptides , Theonella swinhoei
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