Record number :
1101054
Title of article :
Synthesis of 3-azabicyclo[4.1.0]heptane-1-carboxylic acid
Author/Authors :
Carmela Napolitano، نويسنده , , Manuela Borriello، نويسنده , , Francesca Cardullo، نويسنده , , Daniele Donati، نويسنده , , Alfredo Paio، نويسنده , , Stefano Manfredini، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2010
Pages :
6
From page :
5492
To page :
5497
Abstract :
A full study on the synthesis of 3-azabicyclo[4.1.0]heptane-1-carboxylic acid is described. Three different approaches were investigated in order to achieve an efficient synthesis of this unnatural aminoacid. The optimized synthetic route relies upon three key steps: (i) diazomalonate insertion on 4-phtalimido 1-butene, (ii) intramolecular cyclization and (iii) chemoselective reduction of the resulting lactam. Due to its bicyclic nature and conformational constraints, this aminoacid may be an useful building block in medicinal chemistry.
Journal title :
Tetrahedron
Serial Year :
2010
Link To Document :
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