Title of article :
Solvent-free synthesis of penta-substituted pyrroles: one-pot reaction of amine, alkyl acetoacetate, and fumaryl chloride
Abdolali Alizadeh، نويسنده , , Mohadese Babaki، نويسنده , , Nasrin Zohreh، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2009
A novel, convenient, and efficient approach to the synthesis of penta-substituted pyrroles has been reported based on the multicomponent reaction. Solvent-free condition for the formation of enaminones from primary amines and alkyl acetoacetates and itʹs reaction with fumaryl chloride lead to the formation of pyrroles that have halide, CH2CO2H, ester functional groups, and two alkyl substitutions.
Journal title :