Title of article :
Conformationally constrained amino acids: enantiodivergent synthesis of all four stereoisomers of 2-(tetrahydrofuran-2-yl)glycine
Aigars Jirgensons، نويسنده , , Maura Marinozzi، نويسنده , , Roberto Pellicciari، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2005
The first enantiodivergent synthesis of all four possible 2-(tetrahydrofuran-2-yl)glycine stereoisomers is described. The key step of the route is the highly stereocontrolled allylboration of the (S)- or (R)-Garnerʹs aldehydes to give four chiral homoallylalcohols. Starting from them, the title compounds are obtained in five steps.
allylboration , Conformationally constrained amino acids , Garnerיs aldehyde , Unnatural amino acids
Journal title :