Title of article :
Synthesis of 1,2-dihydro-1,3-diaza-2λ5,4λ5-2,4-diphosphorine 2-oxides
Carmen M And?jar، نويسنده , , Isidro Pérez ?lvarez، نويسنده , , Fernando L?pez Ortiz، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2002
The reaction of lithium (N-diphenylphosphoryl)phosphazenes with nitriles afforded 1,2-dihydro-1,3-diaza-2λ5,4λ5-2,4-diphosphorine 2-oxides through a C-regioselective addition to the cyano linkage followed by in situ cyclocondensation. The new heterocycles were designed to mimic thymine and are promising chemotherapeutic anticancer agents. As an exception, for p-nitrobenzonitrile a SNAr reaction was exclusively observed with the nucleophile entering in the ortho position of the nitro substituent in a process directed by the strong electron withdrawing effect of the NO2 group.
phosphazenes , diphosphorines , carbanions , phosphorus heterocycles , SNAr
Journal title :