Record number :
1082640
Title of article :
A new simple route for the synthesis of (±)-2-azetidinones starting from β-enaminoketoesters
Author/Authors :
Carmela De Risi، نويسنده , , Gian Piero Pollini، نويسنده , , Augusto C Veronese، نويسنده , , Valerio Bertolasi، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2001
Pages :
7
From page :
10155
To page :
10161
Abstract :
β-Enaminoketoesters 1, obtained through metal-catalysed reaction of methyl acetoacetate with alkyl cyanoformates have been conveniently transformed into β-aminoesters 4, 5 by reduction of both the carbonyl group and the carbon–carbon double bond of the enaminoester moiety. These intermediates could be easily converted to (±)-2-azetidinones 6, 7 structurally related to thienamycin in good yield and high diastereoselectivity.
Keywords :
2-azetidinones , ?-enaminoketoesters , Diastereoselectivity
Journal title :
Tetrahedron
Serial Year :
2001
Link To Document :
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