Record number :
1021717
Title of article :
Forces in Tissue Morphogenesis and Patterning
Author/Authors :
Carl-Philipp Heisenberg، نويسنده , , Yohanns Bellaïche، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2013
Pages :
15
From page :
948
To page :
962
Abstract :
During development, mechanical forces cause changes in size, shape, number, position, and gene expression of cells. They are therefore integral to any morphogenetic processes. Force generation by actin-myosin networks and force transmission through adhesive complexes are two self-organizing phenomena driving tissue morphogenesis. Coordination and integration of forces by long-range force transmission and mechanosensing of cells within tissues produce large-scale tissue shape changes. Extrinsic mechanical forces also control tissue patterning by modulating cell fate specification and differentiation. Thus, the interplay between tissue mechanics and biochemical signaling orchestrates tissue morphogenesis and patterning in development.
Journal title :
CELL
Serial Year :
2013
Link To Document :
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